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You are here:Home » Antibodies » Abs to Transport Proteins » Anti -LRP, MVP (Major Vault Protein, Lung-resistance Related Protein)

Anti -LRP, MVP (Major Vault Protein, Lung-resistance Related Protein)


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Clone Host Grade Applications
Monoclonal Mouse IH
Major vault protein (MVP) is the main constituent of vaults which are huge intracellular ribonucleoprotein particles, with their structure resembling cathedral roof vaults. Lung resistance-related protein (LRP) was identified as the major MVP. The approximately 55aa residue MVP domain has a unique, novel fold that consists of a three-stranded antiparallel beta-sheet. It functions as a transport associated protein that can be associated with multidrug resistance by reducing cellular accumulation of chemotherapeutic agents. Expression of MVP:LRP has been documented in various tumors adult T-cell leukemia, osteosarcoma, Wilms' tumor, acute leukemia, prostate carcinoma, ovarian carcinoma, acute myeloid leukemia, and non-small-cell lung cancer where it acts as an excellent predictor and marker of multiple drug resistance (MDR). This gene produces two transcripts by using two alternative exon 2 sequences. It is highly expressed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine and overexpressed in many multidrug-resistant cancer cells.
Catalog #L4500-03A
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlBreast
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No11E260
ConcentrationNot determined
FormSupplied as a liquid, 0.05% sodium azide.
ImmunogenProteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells. Cellular Localization: Cytoplasmic.
SpecificityRecognizes rat MVP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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