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You are here:Home » Antibodies » Antibodies-Multi Drug Resistance (MDR) » Anti -LRP, MVP (Lung-resistance Related Protein, Major Vault Protein)

Anti -LRP, MVP (Lung-resistance Related Protein, Major Vault Protein)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH FC
Major vault protein (MVP) is identical to lung resistance related protein (LRP). Its shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocortoid receptors are also able to co-immunoprecipitate the MVP. Reportedly, the lung resistance related protein (LRP) is identical to human MVP. LRP is overexpressed in many neoplasitc tissues and cells lines indicating a poor response to chemotherapy.
Catalog #L4500-06
ApplicationsSuitable for use in Flow Cytometry, Immunoprecipitation, Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunoprecipitation (Native verified): 2ug/mg protein lysate Use Protein G.
Western Blot: 1-2ug/ml for 2 hrs at RT.
Immunohistochemistry (Formalin/paraffin): 1:50-1:100 for 20 minutes at RT. Note: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes.
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlsSKBR3 cells and breast carcinomas
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No0.N.389
FormSupplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See L4500-06X.
PurityPurified by Protein G affinity chromatography.
ImmunogenProteins purified with AER317 from extract of human breast cancer MCF-7 cells. Cellular Localization: Cytoplasmic.
SpecificityRecognizes human LRP, MVP at 104-110kD. Species Crossreactivity: rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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