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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -LRRK2 (Leucine-rich Repeat Kinase 2, RIP7, PARK8, Dardarin)

Anti -LRRK2 (Leucine-rich Repeat Kinase 2, RIP7, PARK8, Dardarin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP IH
LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
Catalog #L4502-20
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionsImmunoprecipitation: 1:100
Western Blot: 1:1000
Immunohistochemistry (Paraffin): 1:500
Optimal dilutions to be determined by the researcher.
Recommended Secondary AntibodiesI1904-39: IgG, X-Adsorbed (HRP) Pab Gt xRb
I1904-40A: IgG, H&L, X-Adsorbed (HRP) Pab Gt xRb
I1904-46Q: IgG, H&L (HRP) Pab Gt xRb
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant Human LRRK2 (leucine-rich repeat kinase 2) (aa1838-2133) is fused at the N-terminus to a tag.
SpecificityRecognizes human LRRK2. The strongest recognized epitope is PDQPRLTIPISQ (aa1843-1854) by mapping.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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