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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -LTK (Leukocyte Tyrosine Kinase Receptor, Protein Tyrosine Kinase 1, TYK1)

Anti -LTK (Leukocyte Tyrosine Kinase Receptor, Protein Tyrosine Kinase 1, TYK1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Leukocyte tyrosine kinase (LTK) is a receptor-type protein tyrosine kinase, belonging to the insulin receptor superfamily, and is mainly expressed in B lymphocyte precursors and neuronal tissues. LTK utilizes insulin receptor substrate-1 (IRS-1) and Shc as major two substrates and possesses two NPXY motifs for them separately, tyrosine 485 of one NPXY motif at the juxtamembrane domain for IRS-1 and tyrosine 862 of another NPXY motif at the carboxyl-terminal domain for Shc. It has also been shown that p85 subunit of PI3 kinase directly binds to tyrosine 753 of LTK, which is located within a YXXM motif. Tyrosine 485 and 753 are responsible for IRS-1 and PI3K mediated survival effects of LTK, respectively.
Catalog #L4725-50C
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 5ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa800-864 of human LTK (KLH).
SpecificityRecognizes human LTK.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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