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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -LTK (Leukocyte Tyrosine Kinase Receptor, Protein Tyrosine Kinase 1, TYK1)

Anti -LTK (Leukocyte Tyrosine Kinase Receptor, Protein Tyrosine Kinase 1, TYK1)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified B IH
LTK is a glycoprotein member of the tyrosine protein kinase family, insulin receptor subfamily of proteins. There are multiple isoforms that run between 50 and 100kD in SDS-Page. It is reportedly expressed in lymphocytes and cerebral cortex neurons, plus cardiomyocytes where it plays a role in cellular hypertrophy. Mature human LTK is an 848aa type I transmembrane protein that is embedded in the ER. It contains a 408aa extracellular domain aa17-424 plus a 415aa cytoplasmic region aa450-864. The cytoplasmic region possesses multiple phosphotyrosines that interact with downstream signaling molecules. There is also a protein kinase domain between aa510-786. LTK apparently undergoes dimer- and trimerization under certain circumstances. There are multiple splice variants for LTK. Two isoforms possess a common deletion of aa274-334 that may be accompanied by a 27aa substitution for aa449-544. Another isoform shows an alternative start site at aa406 accompanied by a 17aa substitution for aa449, while a fourth isoform contains a 51aa substitution for aa171-864. A final 50kD isoform shows a 28aa substitution for aa449-864. Over aa17-424, human LTK shares 75% aa identity with mouse LTK.
Catalog #L4725-50D
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Immunohistochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
Concentration~0.1mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.2mg/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa10-424 from human LTK expressed in NSO cell line.
SpecificityRecognizes human LTK.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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