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Abs to Receptors, Tyrosine Kinase
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Anti -LTK (Leukocyte Tyrosine Kinase Receptor, Protein Tyrosine Kinase 1, TYK1)
Anti -LTK (Leukocyte Tyrosine Kinase Receptor, Protein Tyrosine Kinase 1, TYK1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Affinity Purified |
B IH |
|
| LTK is a glycoprotein member of the tyrosine protein kinase family, insulin receptor subfamily of proteins. There are multiple isoforms that run between 50 and 100kD in SDS-Page. It is reportedly expressed in lymphocytes and cerebral cortex neurons, plus cardiomyocytes where it plays a role in cellular hypertrophy. Mature human LTK is an 848aa type I transmembrane protein that is embedded in the ER. It contains a 408aa extracellular domain aa17-424 plus a 415aa cytoplasmic region aa450-864. The cytoplasmic region possesses multiple phosphotyrosines that interact with downstream signaling molecules. There is also a protein kinase domain between aa510-786. LTK apparently undergoes dimer- and trimerization under certain circumstances. There are multiple splice variants for LTK. Two isoforms possess a common deletion of aa274-334 that may be accompanied by a 27aa substitution for aa449-544. Another isoform shows an alternative start site at aa406 accompanied by a 17aa substitution for aa449, while a fourth isoform contains a 51aa substitution for aa171-864. A final 50kD isoform shows a 28aa substitution for aa449-864. Over aa17-424, human LTK shares 75% aa identity with mouse LTK. | | | Catalog # | L4725-50D | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml | | Immunohistochemistry: 5-15ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Human | | Concentration | ~0.1mg/ml after reconstitution | | Form | Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.2mg/ml. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant corresponding to aa10-424 from human LTK expressed in NSO cell line. | | Specificity | Recognizes human LTK. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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