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You are here:Home » Molecular Biology » MB-Protein Kinase Inhibitors » LY294002 (PI 3 Kinase Inhibitor, 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one)

LY294002 (PI 3 Kinase Inhibitor, 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one)


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LY294002 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. PI3K is an enzyme that phosphorylates the D-3 position of the inositol ring in phosphoinositides, resulting in the formation of PI(3)P, PI(3,4)P2, and PI(3,4,5)P3. LY294002 is a selective PI3K inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4uM, but does not inhibit PI4K, EGF receptor, PDGF receptor, insulin receptor, c-src, MAP kinase, S6 kinase, diacylglycerol kinase, protein kinase A, protein kinase C, and ATPase. LY294002 was shown to completely abolish PI3K activity in fMet-Leu-Phe- stimulated human neutrophils, as well as, inhibit proliferation of smooth muscle cells in cultured rabbit aortic segments.
Catalog #L7751-01
SolubilityAs Reported
Melting PointAs Reported
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with DMSO, ethanol or dimethyl formamide. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number154447-36-6
Molecular FormulaC19H17NO3
Molecular Weight307.34
FormAs Reported
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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