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Anti -Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA)
Anti -Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Purified |
B IP IH FC |
|
| CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles.1 It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion.2 CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and Beige mutant mice.3 LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases.4 | | | Catalog # | L9190-08 | | Applications | Suitable for use in Flow Cytometry, Immunohistochemistry, Immunoaffinity chromatography, Immunoprecipitation, Western Blot and Immunoelectron microscopy. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1ug/10e6 cells | | Immunohistochemistry: Frozen sections | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a,k | | Clone No | 1D4B | | Host | Rat | | Source | Mouse | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in 100mM borate buffered saline, pH 8.0, before the addition of glycerol to 40%. | | Purity | Purified | | Immunogen | Plasma membrane fraction of mouse embryo NIH3T3 cell line | | Specificity | Recognizes mouse CD107a/LAMP-1 (Mr 110-140kD with a core protein of Mr ~40kD). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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