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You are here:Home » Antibodies » Abs to CD Markers » Anti -Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA)

Anti -Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified B IP IH FC
CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles (1). It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion (2). CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and Beige mutant mice (3). LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases (4).
Catalog #L9190-08
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry, Immunoaffinity chromatography, Immunoprecipitation, Western Blot and Immunoelectron microscopy. Other applications not tested.
Recommended DilutionFlow Cytometry: 1ug/10e6 cells
Immunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No1D4B
HostRat
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in 100mM borate buffered saline, pH 8.0.
PurityPurified
ImmunogenPlasma membrane fraction of mouse embryo NIH3T3 cell line
SpecificityRecognizes mouse CD107a/LAMP-1 (Mr 110-140kD with a core protein of Mr ~40kD).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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