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You are here:Home » Antibodies » Abs to CD Markers » Anti -Lysosome Associated Membrane Protein 2 (LAMP 2, CD107b, Igp2, Igp110) (PE)

Anti -Lysosome Associated Membrane Protein 2 (LAMP 2, CD107b, Igp2, Igp110) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH FC
CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.
Catalog #L9190-14C
ApplicationsSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 10ul labels 10e6 cells.
Immunohistochemistry: Acetone-fixed, frozen tissue sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5K77
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Labeled with R-Phycoerythrin (PE).
PurityPurified
ImmunogenHuman LAMP-2.
SpecificityRecognizes human CD107b/ LAMP 2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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