You are here:Home
»
Antibodies
»
Abs to Membrane Proteins
»
Anti -Lysosome Associated Membrane Protein 2 (LAMP 2, CD107b, Igp2, Igp110)
Anti -Lysosome Associated Membrane Protein 2 (LAMP 2, CD107b, Igp2, Igp110)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP FC IF |
|
| Lysosomes are membrane-bound organelles found within the cytoplasm of most cells, which contain hydrolytic enzymes and act as the major compartment for heterophagic and autophagic digestion. Members of the lysosomal-associated membrane protein family (LAMPS) are believed to play an important role in protecting the lysosomal membrane from protease degradation and are involved in lectin-mediated cell adhesion. Evidence shows that CD107b is involved in the lysosomal uptake of cytosolic proteins and the endocytic pathway and human studies have revealed a correlation between the level of surface expression of CD107b on tumor cells and their metastatic potential. | | | Catalog # | L9190-15D | | Applications | Suitable for use in Western Blot, Electron Microscopy, Immunoprecipitation, Immunofluorescence and Flow Cytometry. Other applications not tested. | | Recommended Dilutions | Western Blot: 1:100-1:500 | | Flow Cytometry: 10ul labels 1x10e6 cells in 100ul. Membrane permeabilization is required for this application. | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Spleen cells from immunized BALB/c mice were fused with cells of the NS1 myeloma cell line. | | Recommended Negative Control | I1904-78R: IgG1 Murine Negative Control | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9A182 | | Host | Mouse | | Source | Canine | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | MDCK (Madin-Darby Canine Kidney) cells. | | Specificity | Recognizes canine CD107b, a 95kD heavily-glycosylated type I integral lysosomal glycoprotein. Demonstrates staining pattern consistant with localization to lysosome. | | Species Crossreactivity | Human and mink. Does not react with mouse or rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
