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You are here:Home » Antibodies » Abs to Membrane Proteins » Anti -Lysosome Associated Membrane Protein 2 (LAMP 2, CD107b, Igp2, Igp110)

Anti -Lysosome Associated Membrane Protein 2 (LAMP 2, CD107b, Igp2, Igp110)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP FC IF
Lysosomes are membrane-bound organelles found within the cytoplasm of most cells, which contain hydrolytic enzymes and act as the major compartment for heterophagic and autophagic digestion. Members of the lysosomal-associated membrane protein family (LAMPS) are believed to play an important role in protecting the lysosomal membrane from protease degradation and are involved in lectin-mediated cell adhesion. Evidence shows that CD107b is involved in the lysosomal uptake of cytosolic proteins and the endocytic pathway and human studies have revealed a correlation between the level of surface expression of CD107b on tumor cells and their metastatic potential.
Catalog #L9190-15D
ApplicationsSuitable for use in Western Blot, Electron Microscopy, Immunoprecipitation, Immunofluorescence and Flow Cytometry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:100-1:500
Flow Cytometry: 10ul labels 1x10e6 cells in 100ul. Membrane permeabilization is required for this application.
Optimal dilutions to be determined by the researcher.
HybridomaSpleen cells from immunized BALB/c mice were fused with cells of the NS1 myeloma cell line.
Recommended Negative ControlI1904-78R: IgG1 Murine Negative Control
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9A182
HostMouse
SourceCanine
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenMDCK (Madin-Darby Canine Kidney) cells.
SpecificityRecognizes canine CD107b, a 95kD heavily-glycosylated type I integral lysosomal glycoprotein. Demonstrates staining pattern consistant with localization to lysosome.
Species CrossreactivityHuman and mink. Does not react with mouse or rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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