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You are here:Home » Growth Factors, Cytokines » Growth Factors-MIP » Macrophage Inflammatory Protein 1 alpha, Recombinant, Human (MIP-1 alpha, CCL3, LD78 alpha)

Macrophage Inflammatory Protein 1 alpha, Recombinant, Human (MIP-1 alpha, CCL3, LD78
alpha)

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Specifications

Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells.
Catalog #M1202
Recombinant human MIP-1 alpha is a 7.8kD protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Sequence ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA
Source E. coli
Form Lyophilized protein with no additives.
Stability The lyophilized protein, though stable at room temperature, is best stored desiccated below 0°C.
Purity 99% by SDS-PAGE and HPLC analysis.
Endotoxin 0.1 ng/ug
Reconstitution Lyophilized MIP-1alpha is soluble in water and most aqueous buffers and can be reconstituted in water to a concentration of 0.1mg/ml. This solution can be diluted into other buffered solutions or stored frozen for future use.
Biological Activity The maximal chemotactic activity of human MIP-1alpha on human monocytes was achieved at 50ng/ml.
Molecular Weight 7.8kD
Responding Cells (partial list) Monocytes, stem cells
Concentration Range for most in vitro applications 5.0-50ng/ml
Molecular Weight7.8kD
SourceE. coli
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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