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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -Macrophage Stimulating 1 Receptor (MST1R, Ron, c-Met Related Tyrosine Kinase, CD136, CDw136, Macrophage Stimulating Protein Receptor alpha Chain, Macrophage Stimulating Protein Receptor beta Chain, MSP Receptor, Protein Tyrosine Kinase 8, PTK8, RON Protei

Anti -Macrophage Stimulating 1 Receptor (MST1R, Ron, c-Met Related Tyrosine Kinase, CD136,
CDw136, Macrophage Stimulating Protein Receptor alpha Chain, Macrophage Stimulating
Protein Receptor beta Chain, MSP Receptor, Protein Tyrosine Kinase 8, PTK8, RON Protei

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
CD136 is a receptor tyrosine kinase also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d’origine nantais). CD136 is a member of the MET proto-oncogene family, and is the receptor for macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival.
CD136 is a disulfide-linked 180kD heterodimer composed of a 40kD alpha chain and a 150kD beta chain, and is mainly expressed in cells of epithelial origin. In immune cells CD136 expression is restricted to certain types of tissue macrophages, and its activation is critical in modulating macrophage activities and preventing an excessive inflammatory response. CD136 is also required for embryonic development.
CD136 expression is significantly altered in several primary human cancers including those of the breast and colon.
Catalog #M1204-01E
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 5ug/ml
Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.
Positive Control TissueColon, surface epithelium.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to an internal domain of human CD136 (KLH).
SpecificityRecognizes human Macrophage Stimulating 1 Receptor.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=2.7.10.1


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