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Anti -MAdCAM-1 (Mucosal Addressin Cell Adhesion Molecule 1)
Anti -MAdCAM-1 (Mucosal Addressin Cell Adhesion Molecule 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH FC |
|
| Human mucosal addressin cell adhesion molecules-1 (MAdCAM-1), a key player in mediating the infiltration of leukocytes into chronically inflamed tissue. MAdCAM-1 is a cell-surface Ig superfamily member composed of two extracellular Ig domains, followed by a mucin-like domain, a transmembrane domain and a short cytoplasmatic domain. It interacts via its N- terminal Ig domain with the lymphocyte homing receptor alpha4beta7, which plays a critical role in forming the gut-associated lymphoid system. MAdCAM-1 promotes the adhesion of T- and B cells, monocytes/macrophages, and potentially eosinophils, basophils, and differentiated mast cells to the vascular endothelium. Mucosal addressin cell adhesion molecule-1 RNA transcripts are predominantly expressed in the small intestine, mesenteric lymph nodes, colon and spleen; and are very weakly expresssed in human pancreas and brain. MAdCAM-1 is strongly expressed in the synovium of osteoarthritis patients, predominantly on the endothelial lining of blood vessels, but also within the vessel lumen. | | | Catalog # | M1275-04 | | Applications | Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, ELISA and inhibition of biological activity. Other applications have not been tested. | | Recommended Dilutions | | | Immunohistochemistry (frozen, paraffin-embedded sections): 1:50 | | ELISA: 1:50 | | Western Blot: 1:50 | | Flow Cytometry: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 314G8 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% BSA. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Human Mucosal Addressin Cell Adhesion Molecules-1 | | Specificity | Recognizes a site in the N- terminal Ig domain of human mucosal addressin cell adhesion molecules-1 (MAdCAM-1). Detects MAdCAM-1 on venules in the spleen and small intestine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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