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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -MAD2L1 (Mitotic Spindle Assembly Checkpoint Protein MAD2A, MAD2-like 1, MAD2-like Protein 1, Homolog of MAD2 (S. cerevisiae), HsMAD2, Human Mitotic Feedback Control Protein Madp2, MAD2, MAD2 Mitotic Arrest Deficient-like 1, MAD2A, MD2L1, Mitotic Arrest De

Anti -MAD2L1 (Mitotic Spindle Assembly Checkpoint Protein MAD2A, MAD2-like 1, MAD2-like
Protein 1, Homolog of MAD2 (S. cerevisiae), HsMAD2, Human Mitotic Feedback Control Protein
Madp2, MAD2, MAD2 Mitotic Arrest Deficient-like 1, MAD2A, MD2L1, Mitotic Arrest De

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation. Recent studies indicate that the spindle checkpoint monitors both the attachment of chromosomes to the mitotic spindle and the tension across the sister chromatid generated by microtubules. Upon checkpoint activation, checkpoint protein complexes containing BubR1(Mad3), Bub3, Mad2 and Cdc20 directly bind to the anaphase-promoting complex and inhibit its ligase activity. Therefore, the checkpoint proteins form a complex intracellular signalling network to inhibit the anaphase-promoting complex.
Catalog #M1499-15C
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormAs reported
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide which maps to a region between residues 100 and 150 of human Mitotic Arrest Deficient 2 using the numbering given in SwissProt entry Q13257 (GeneID 4085).
SpecificitySpecific for human MAD2 protein. Other species not tested. Reactivity with mouse MAD2 is unlikely.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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