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You are here:Home » Antibodies » Antibodies-Cancer Markers » Anti -MAGE A

Anti -MAGE A


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH IC IF
The MAGE-A protein is expressed in many types of tumors including melanoma, breast and lung. However, in normal tissues, it is only present in adult testis and placenta. The family of MAGE-A proteins includes MAGE-1, -2, -3, -4, -6, -10, and -12. MAGE-1, -3, -6 and -10 are able to recognize specific cytolytic T lymphocytes derived from tumors or peripheral blood. Additionally, MAGE-3 shows HLA class II restricted epitopes. Therefore, MAGE-A is regarded as a possible
immunotherapy candidate, with clinical studies currently underway involving immunization with MAGE-1 and -3 peptides.
Catalog #M1750-01D
ApplicationsSuitable for use in ELISA, Immunocytochemistry, Immunohistochemistry, Immunofluorescence, Immunoprecipitation and Western Blot. Other applications have not been tested.
Recommended DilutionELISA (Native): 0.1-1ug/ml
Immunocytochemistry: 10ug/ml
Immunohistochemistry (Frozen sections): 10ug/ml
Immunofluorescence: 10ug/ml
Immunoprecipitation (Native): 10ug/ml
Western Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlsHuman SK-MEL-37 melanoma cell lysates.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
CAS NumberN/A
Clone TypeMonoclonal
Clone No6A111
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein A chromatography.
ImmunogenFull-length recombinant human MAGE-A
SpecificityRecognizes different members of the human MAGE-A family: MAGE-1, -2, -3, -4, -6, -10 and -12. MAGE-10 has a molecular weight of ~72kD. The rest of the MAGE-A proteins have molecular weights ~45-50kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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