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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -MKRN1 (E3 Ubiquitin-protein Ligase Makorin-1, RING Finger Protein 61, RNF61)

Anti -MKRN1 (E3 Ubiquitin-protein Ligase Makorin-1, RING Finger Protein 61, RNF61)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
MKRN1 (Makorin ring finger protein 1) is a a ubiquitously expressed novel RING zinc finger protein, a member of the Makorin family of proteins. The MKRN gene family encodes putative ribonucleoproteins with a distinctive array of zinc finger motifs, including two to four C(3)H zinc fingers, an unusual Cys/His arrangement that may represent a novel zinc finger structure, and a highly conserved RING zinc finger. So far, nine MKRN family loci have been found distributed throughout the human genome. The MKRN1 gene is highly transcribed in mammals. The MKRN1 protein has been shown to act as an E3 ubiquitin ligase and may represent a nuclear protein with multiple nuclear functions, including the regulation of RNA polymerase II catalyzed transcription.
Catalog #M2112-25D
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:64,000
Western Blot: 0.3-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-RYEHSKPLKQEEAT, from human MKRN1, at the internet regoin of the protein (NP_038474.2, NP_001138597.1).
SpecificityRecognizes human MKRN1. Species sequence homology: Bovine, canine, mouse and porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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