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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Munc18

Anti -Munc18

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH
Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part to its ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein (Sassa et al., 1996).
Catalog #M2197-02
ApplicationsSuitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000
Immunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS NumberN/A
Clone TypePolyclonal
HostRabbit
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by epitope-affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa58-70, V58EDINKRREPIPS70 of human Munc-18.
SpecificityRecognizes Munc at ~67kDa by Western Blot. Species Crossreactivity: mouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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