Anti -Munc-18, phosphorylated (Ser515) (Mammalian Homolog of Unc-18, Munc18, hUNC18,
Munc18-1, Munc18a, N-Sec1, p67, Rbsec1, Syntaxin Binding Protein 1, STXBP1, UNC18, UNC-18,
Unc18 Homolog, Unc-18 Homolog, Unc 18-1, Unc-18-1, Unc18A, Unc-18A)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part to its ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein (Sassa et al., 1996). | | | Catalog # | M2197-03 | | Positive Control | Rat cortex lysate | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | 10 mM Hepes (pH7.5), 150 mM NaCl, 100 ug/ml BSA and 50% glycerol | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser515 of Munc-18. Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns. | | Specificity | The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, human, mouse, non-human primates and Xenopus based on the fact that these species have 100% homology with the amino acid sequence used as antigen. Specific for the ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Munc-18, phosphorylated (Ser515) (Mammalian Homolog of Unc-18, Munc18, hUNC18, Munc18-1, Munc18a, N-Sec1, p67, Rbsec1, Syntaxin Binding Protein 1, STXBP1, UNC18, UNC-18, Unc18 Homolog, Unc-18 Homolog, Unc 18-1, Unc-18-1, Unc18A, Unc-18A) |
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