Anti -MUNC-18, phosphorylated (Ser515) (Mammalian Homolog of Unc-18, Munc18, hUNC18,
Munc18-1, Munc18a, N-Sec1, p67, Rbsec1, Syntaxin Binding Protein 1, STXBP1, UNC18, UNC-18,
Unc18 Homolog, Unc-18 Homolog, Unc 18-1, Unc-18-1, Unc18A, Unc-18A, Protein Unc-18 Ho
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| Munc-18 phosphorylated at serine 515 is a 67kD member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25kD (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release. | | | Catalog # | M2197-03C | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | As reported | | Form | Supplied as a liquid in 10mM Hepes, pH 7.5, 0.09% sodium azide, 0.01% BSA, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18. | | Specificity | Recognizes rat Munc-18 phosphorylated at serine 515. Species sequence homology: Dog, Xenopus, Human, Bovine, Chicken, Mouse, Primate. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -MUNC-18, phosphorylated (Ser515) (Mammalian Homolog of Unc-18, Munc18, hUNC18, Munc18-1, Munc18a, N-Sec1, p67, Rbsec1, Syntaxin Binding Protein 1, STXBP1, UNC18, UNC-18, Unc18 Homolog, Unc-18 Homolog, Unc 18-1, Unc-18-1, Unc18A, Unc-18A, Protein Unc-18 Ho |
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