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You are here:Home » Antibodies » Abs to Golgi Proteins » Anti -Mannose 6 Phosphate Receptor, Cation-independent (MPR, 300kD Mannose 6 Phosphate Receptor, Cation Independent Mannose 6 Phosphate Receptor, CI Man-6-P Receptor, CI-MPR, CIMPR, CD222, Insulin-like Growth Factor 2 Receptor, IGF2 Receptor, IGF2R, Insulin-lik

Anti -Mannose 6 Phosphate Receptor, Cation-independent (MPR, 300kD Mannose 6 Phosphate
Receptor, Cation Independent Mannose 6 Phosphate Receptor, CI Man-6-P Receptor, CI-MPR,
CIMPR, CD222, Insulin-like Growth Factor 2 Receptor, IGF2 Receptor, IGF2R, Insulin-lik

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IP IF
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of 300kD cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and ~10 % at cell surface.
In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ~240kD soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.
Catalog #M2255-16
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No8L641
HostMouse
SourceBovine
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
PurityPurified
ImmunogenPurified bovine 300 kDa CI-MPR. Epitope: This antibody is shown to recognize an epitope in the extracellular domain of MPR.
SpecificitySpecies Crossreactivity: Crossreacts with Human, bovine and Non Human Primates.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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