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You are here:Home » Antibodies » Abs to Microtubule-associated Proteins » Anti -MAP2 (Microtubule Associated Protein 2, Dendrite Specific MAP, DKFZp686I2148, MAP2A, MAP2B, MAP2C, Mtap2, Mtap-2)

Anti -MAP2 (Microtubule Associated Protein 2, Dendrite Specific MAP, DKFZp686I2148, MAP2A,
MAP2B, MAP2C, Mtap2, Mtap-2)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Serum B IF
Microtubules are 25nm diameter protein rods found in most kinds of eukarytic cells. They are polymerized from a dimeric subunit made of one a subunit and one b tubulin subunit. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein t (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5. MAP2 is made up of two ~280kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70kDa on SDS-PAGE gels. Antibodies to MAP2 are excellent markers on neuronal cells, their perikarya and neuronal dendrites. In contrast t (tau) is found predominantly in neuronal axons.
Dendrite specific MAP is found specifically in the dendritic branching of neurons.
Catalog #M2349-98E
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50%glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
Concentration~19mg/ml
FormAs reported
PurityWhole antisera
ImmunogenRaised against all three MAP2 forms, derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences,
which are very similar to those found in the related microtubule binding protein t (tau). MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells.
SpecificitySpecies Crossreactivity: This antibody reacts with human, rat, mouse and bovine protein. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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