Anti -MAP Kinase p38 alpha (MAPK14, Mitogen-activated Protein Kinase p38 alpha,
Mitogen-activated Protein Kinase 14, CSBP, Cytokine Suppressive Anti-inflammatory
Drug-binding Protein, CASID-binding Protein, SAPK2A, CSBP, CSBP1, CSBP2, CSPB1, MXI2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IH |
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| P38 MAP kinase (MAPK), also called RK (3) or CSBP (2), is the mammalian homologue of the yeast HOG kinase and participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAP kinase, alpha, beta, gamma and delta, have been identified so far. Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (1-5). MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr180 and Tyr182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6) and MEF2 (5-8). | | | Catalog # | M2352-01A | | Applications | Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Immunoprecipitation: 1:100 | | Immunohistochemistry (Paraffin): 1:50. Requires antigen retrieval using citrate method. Antibody diluten: TBST/5% normal goat serum | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, and 50% glycerol. | | Purity | Purified by protein A and peptide affinity chromatography. | | Immunogen | Synthetic peptide (KLH coupled) corresponding to the C-terminal residues of human p38 MAP kinase alpha. | | Specificity | Detects endogenous levels of total p38 MAP kinase alpha isoform independent of phosphorylation. Does not crossreact with other p38 MAP kinase isoforms such as beta, gamma or delta. Species Crossreactivity: Human, mouse, rat and monkey. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=2.7.11.24 |
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Download Specifications for Anti -MAP Kinase p38 alpha (MAPK14, Mitogen-activated Protein Kinase p38 alpha, Mitogen-activated Protein Kinase 14, CSBP, Cytokine Suppressive Anti-inflammatory Drug-binding Protein, CASID-binding Protein, SAPK2A, CSBP, CSBP1, CSBP2, CSPB1, MXI2) |
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