Anti -MAP Kinase 14, phosphorylated (Thr180, Tyr182) (Mitogen-activated Protein Kinase 14,
MAPK 14, MAPK14, Mitogen-activated Protein Kinase p38alpha, MAP Kinase p38alpha, Cytokine
Suppressive Anti-inflammatory Drug binding Protein, CSAID Binding Protein, CSBP,
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E Gel |
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| MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. | | | Catalog # | M2352-03T | | Applications | Suitable for use in ELISA and Dot Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Dot Blot: 1:500 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic bisphosphopeptide incorporating amino acid residues surrounding phosphorylated Thr180 and Tyr182 of human MAPK14 (KLH). | | Specificity | Recognizes human MAPK14 when phosphorylated at Thr180 and Tyr182. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=2.7.11.24 |
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Download Specifications for Anti -MAP Kinase 14, phosphorylated (Thr180, Tyr182) (Mitogen-activated Protein Kinase 14, MAPK 14, MAPK14, Mitogen-activated Protein Kinase p38alpha, MAP Kinase p38alpha, Cytokine Suppressive Anti-inflammatory Drug binding Protein, CSAID Binding Protein, CSBP, |
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