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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -MARCH8, CT (E3 Ubiquitin-protein Ligase MARCH8, Membrane-associated RING Finger Protein 8, Membrane-associated RING-CH Protein VIII, MARCH-VIII, RING Finger Protein 178, Cellular Modulator Of Immune Recognition, c-MIR, MARCH8, MIR, RNF178)

Anti -MARCH8, CT (E3 Ubiquitin-protein Ligase MARCH8, Membrane-associated RING Finger
Protein 8, Membrane-associated RING-CH Protein VIII, MARCH-VIII, RING Finger Protein 178,
Cellular Modulator Of Immune Recognition, c-MIR, MARCH8, MIR, RNF178)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH IC
MARCH8 is an E3 ubiquitin-protein ligase that may regulate immune responses by promoting ubiquitination of MHC-II and CD86, which leads to their subsequent endocytosis and lysosomal degradation. May also promote ubiquitination and endocytosis of TFRC and FAS. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Catalog #M2374-88A
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Immunocytochemistry: 2.5ug/ml
Optimal dilutions to be determined by the researcI
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 17aa from near the C-terminus of human MARCH8.
SpecificityRecognizes human MARCH8. Species sequence homology: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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