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You are here:Home » Antibodies » Abs to Protein Kinase Substrates » Anti -MARCKS, phosphorylated (Ser152/156) (Myristolated Alanine Rich C Kinase Substrate, Myristoylated Alanine Rich Protein Kinase C Substrate, MACS, MARCS, 80K-L Protein, 81kD Protein Light Chain, MGC52672, Phosphomyristin, PKCSL, PRKCSL, Protein Kinase C Subs

Anti -MARCKS, phosphorylated (Ser152/156) (Myristolated Alanine Rich C Kinase Substrate,
Myristoylated Alanine Rich Protein Kinase C Substrate, MACS, MARCS, 80K-L Protein, 81kD
Protein Light Chain, MGC52672, Phosphomyristin, PKCSL, PRKCSL, Protein Kinase C Subs

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
MARCKS is a member of the calmodulin binding protein family, is localised to the plasma membrane, forming cross-links with actin filaments. Phosphorylation by protein kinase C at key serine residues results in inhibition of binding to actin, phosphatidyl serine and calmodulin.
MARCKS is thought to be involved in mitogenesis, phagocytosis and membrane trafficking.
The specificity of this antibody has been shown by blocking studies in Western blotting, whereby staining was blocked by the phosphopeptide. No blocking was seen by the corresponding non-phosphopeptide.
Catalog #M2375-05D
ApplicationsSuitable for use in Western Blot and Immunohistochemistry (frozen). Other applications not tested.
Recommended DilutionWestern Blot:1:1000, detects a band of approximately 87kD in rat brain lysates.
Optimal dilution determined by the researcher.
Recommended Secondary ReagentsSheep anti rabbit IgG:HRP
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
FormSupplied as a liquid in 10mM HEPES, pH 7.5, 0.1% BSA, 0.09% BSA and 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to an amino acid sequence within MARCKS which includes phosphorylated serine 152 and 156.
SpecificitySpecific for Myristoylated alanine-rich protein kinase C substrate (MARCKS), when phosphorylated at serine 152 and 156. Species Cross Reactivity: Human, mouse, rat and xenopus (100% identity with immunogen sequence).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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