Anti -MARCKS, phosphorylated (Ser152/156) (myristoylated alanine-rich protein kinase C
substrate, 80K-L, 80K-L Protein, FLJ14368, FLJ90045, MACS, Myristoylated alanine-rich
C-kinase substrate, PKCSL, PRKCSL, Protein kinase C substrate, 80kD Protein, Light Chain
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
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| Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) is a widely expressed substrate of PKC. MARCKS is essential in neuronal development, as mice deficient in it die shortly after birth. Through its basic effector region, MARCKS associates with acidic membrane phospholipids, actin filaments, and calmodulin. Poly (ADP-ribose) also binds the basic effector region, blocking calmodulin binding, membrane association, and phosphorylation by PKC, suggesting that MARCKS may be an effector of the DNA-damage signal transduced by poly (ADP-ribose). | | | Catalog # | M2375-05E | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500 | | Immunohistochemistry (paraffin): 1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | A431 Cell Lysate | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Rat | | Concentration | As reported | | Form | Supplied as a liquid in 10mM Hepes, pH 7.5, 150mM sodium chloride, 100ug/mL BSA, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to amino acids surrounding the phosphoSer152/156 of rat MARCKS. | | Specificity | Recognizes rat MARCKS when phosphorylated at Ser152/156. . Species Crossreactivity: mouse, human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -MARCKS, phosphorylated (Ser152/156) (myristoylated alanine-rich protein kinase C substrate, 80K-L, 80K-L Protein, FLJ14368, FLJ90045, MACS, Myristoylated alanine-rich C-kinase substrate, PKCSL, PRKCSL, Protein kinase C substrate, 80kD Protein, Light Chain |
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