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You are here:Home » Antibodies » Abs to Protein Kinase Substrates » Anti -MARCKS, phosphorylated (Ser152/156) (myristoylated alanine-rich protein kinase C substrate, 80K-L, 80K-L Protein, FLJ14368, FLJ90045, MACS, Myristoylated alanine-rich C-kinase substrate, PKCSL, PRKCSL, Protein kinase C substrate, 80kD Protein, Light Chain

Anti -MARCKS, phosphorylated (Ser152/156) (myristoylated alanine-rich protein kinase C
substrate, 80K-L, 80K-L Protein, FLJ14368, FLJ90045, MACS, Myristoylated alanine-rich
C-kinase substrate, PKCSL, PRKCSL, Protein kinase C substrate, 80kD Protein, Light Chain

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) is a widely expressed substrate of PKC. MARCKS is essential in neuronal development, as mice deficient in it die shortly after birth. Through its basic effector region, MARCKS associates with acidic membrane phospholipids, actin filaments, and calmodulin. Poly (ADP-ribose) also binds the basic effector region, blocking calmodulin binding, membrane association, and phosphorylation by PKC, suggesting that MARCKS may be an effector of the DNA-damage signal transduced by poly (ADP-ribose).
Catalog #M2375-05E
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500
Immunohistochemistry (paraffin): 1:100
Optimal dilutions to be determined by the researcher.
Positive ControlA431 Cell Lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid in 10mM Hepes, pH 7.5, 150mM sodium chloride, 100ug/mL BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acids surrounding the phosphoSer152/156 of rat MARCKS.
SpecificityRecognizes rat MARCKS when phosphorylated at Ser152/156. . Species Crossreactivity: mouse, human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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