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Maspin, Recombinant, Human (Mammary-specific Serpin, SERPINB5, Protease inhibitor 5)
Maspin, Recombinant, Human (Mammary-specific Serpin, SERPINB5, Protease inhibitor 5)
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| Maspin or mammary-specific serpin is a tumor suppressor protein of serine proteinase inhibitor family. Its transcription is regulated in combinatorial fashion by Ets, p53 and AP-1. It is present in normal breast and prostatic epithelial cells but downregulated in the respective carcinomas. The extent of downregulation correlates with the progression of the carcinoma and may help in prognosis. Maspin has the ability to block the growth, invasiveness, and metastatic potential of breast and lung tumors. This anti-tumor activity is achieved, in part, by the ability of Maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells. | | | Catalog # | M2412-50B | | Applications | Suitable for use in ELISA, Western Blotting, Inhibition Assays. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months. | | Source | Recombinant protein encoding human | | maspin aa1-200 expressed in E. coli. | | Purity | Purified recombinant protein shows a band at 48kD including GST ( SDS-PAGE commassie blue) | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in 50mM Tris-Acetate, pH 7.5, 1mM EDTA, 20% glycerol.. No stabilizing proteins added. No preservative added. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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