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You are here:Home » Molecular Biology » MB-Protease Inhibitors » Maspin, Recombinant, Human (Mammary-specific Serpin, SERPINB5, Protease inhibitor 5)

Maspin, Recombinant, Human (Mammary-specific Serpin, SERPINB5, Protease inhibitor 5)

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Specifications

Maspin or mammary-specific serpin is a tumor suppressor protein of serine proteinase inhibitor family. Its transcription is regulated in combinatorial fashion by Ets, p53 and AP-1. It is present in normal breast and prostatic epithelial cells but downregulated in the respective carcinomas. The extent of downregulation correlates with the progression of the carcinoma and may help in prognosis. Maspin has the ability to block the growth, invasiveness, and metastatic potential of breast and lung tumors. This anti-tumor activity is achieved, in part, by the ability of Maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells.
Catalog #M2412-50C
Recombinant human Maspin is a 42.2kD non-glycosylated protein containing 375 amino acid residues.
AA SequenceMDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTRNIIFFG KFCSP
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, carrier protein. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceRecombinant protein expressed in E. coli.
Purity90% by SDS-PAGE gel and HPLC analyses. Endotoxin:
0.1ng/ug (1EU/ug)
FormSupplied as a lyophilized powder from sodium phosphate, pH 7.5.
Reconstitute with sterile ddH2O, carrier protein to 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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