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You are here:Home » Antibodies » Antibodies-Enzymes, Protease (Proteinase, Peptidase) » Anti -Mast Cell Tryptase (Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1)

Anti -Mast Cell Tryptase (Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1,


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Human tryptases are divided into two groups, alpha and beta. beta-Tryptase appears to be the major type stored in mast cell secretory granules and alpha-tryptase is the major isoform expressed by basophils. beta-tryptase, a major constituent of mast cell secretory granules, has emerged recently as the most specific marker in vivo of mast cell activation in humans. It is a trypsin like serine protease that hydrolyzes peptide bonds on the C-terminal side of basicaa. Unlike trypsin, however, it is highly selective in hydrolyzing its peptide and protein targets and resists inactivation by circulating inhibitors. It has potential roles in the lung, skin, and other tissues as a local anticoagulant, activator of collagenase, promoter of smooth muscle contraction, and modulator of neuropeptide activity. The pathogenic role for tryptases has been observed in asthmatic airway inflammation other inflammatory disorders. The gene is mapped on human chromosome 16p13.3.
Catalog #M2415-01D
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin-fixed paraffin sections): 1:10,000
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No12H35
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman mast cell tryptase purified from human lung tissue.
SpecificityRecognizes human mast cell tryptase, both alpha and beta isoforms. Species Crossreactivity: feline, canine and monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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