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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-1 (Interstitial Collagenase, Fibroblast Collagenase, Matrix Metalloproteinase-1, MMP1, CLG)

Anti -MMP-1 (Interstitial Collagenase, Fibroblast Collagenase, Matrix Metalloproteinase-1,
MMP1, CLG)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) is implicated in the invasive potential of malignant tumors. Interstitial collagenase (MMP-1), 72kD gelatinase A/type IV collagenase (MMP-2), and 92kD gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis. MMP-1 (collagenase 1) is involved in tumor development and metastasis, and rheumatoid arthritis. It is proposed as a therapeutic target for these diseases.
Catalog #M2420-02Q
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1,000 or 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to collagenase-1 from the hinge region of human MMP-1.
SpecificityRecognizes human MMP-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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