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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-1 (Interstitial Collagenase, Fibroblast Collagenase, Matrix Metalloproteinase-1, MMP1, CLG)

Anti -MMP-1 (Interstitial Collagenase, Fibroblast Collagenase, Matrix Metalloproteinase-1,
MMP1, CLG)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) is implicated in the invasive potential of malignant tumors. Interstitial collagenase (MMP-1), 72kD gelatinase A/type IV collagenase (MMP-2), and 92kD gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis.
Catalog #M2420-05A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml for 2h at RT
Optimal dilutions to be determined by the researcher.
Positive ControlConditioned, serum-free medium from (TPA-treated) HFL-1 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No2D2
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman native collagenase-1.
SpecificityRecognizes human MMP-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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