You are here:Home
»
Antibodies
»
Abs to Matrix Metalloproteinases
»
Anti -MMP-2 (72kD Type IV Collagenase, 72kD Gelatinase, Gelatinase A, Matrix Metalloproteinase-2, TBE-1, MMP2, CLG4A)
Anti -MMP-2 (72kD Type IV Collagenase, 72kD Gelatinase, Gelatinase A, Matrix
Metalloproteinase-2, TBE-1, MMP2, CLG4A)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IH |
|
| MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved aa sequence in the putative metal binding-active site region, and inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play a significant role in regulating angiogenesis. MMP-2; also known as 72kD collagenase IV or gelatinase A is synthesized as a 631aa proenzyme, which is activated by cleavage of the first 80aa into an active form of 62kD. This antibody reacts with only the proform of MMP-2 and shows no cross-reaction with pro and active forms of MMP-9. | | | Catalog # | M2420-50A | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml for 2h, RT | | Immunohistochemistry: 1:50 for 30min at RT | | Optimal dilutions to be determined by the researcher. | | Positive Control | Conditioned, serum-free medium from (TPA-treated) human large cell lymphoma U937 cells, placenta | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | SPM346 | | Host | Mouse | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to procollagenase IV at N-terminus. | | Specificity | Recognizes MMP-2. Species Crossreactivity: human, mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
