Anti -MMP2 (72kD Type IV Collagenase, 72kD Gelatinase, Matrix Metalloproteinase-2, MMP-2,
Gelatinase A, TBE-1, CLG4A)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| Matrix metalloproteinase-2 (MMP2) is a Type IV collagenase, 72kD, which is also known as gelatinase and is a member of a group of secreted zinc metalloproteases. The MMP2 gene is 17kb long with 13 exons varying in size from 110-901bp and 12 introns ranging from 175 to 4,350bp 3, located within a region of human chromosome 16q13. In addition,The extra exons encode the aa of the fibronectin-like domain which has so far been found in only the 72-92kD type IV collagenase. MMP2, which has a critical role in the binding of progelatinase A and TIMP4 via the C-terminal hemopexin-like domain (C domain), is functionally associated on the surface of angiogenic blood vessels. NOT only is a likely effector of endometrial menstrual breakdown, MMP2 is also effector and regulator of the inflammatory response. Moreover, MMP2 could be helpful in diagnosing Takayasu arteritis. | | | Catalog # | M2420-52Q | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (FFPE): 15ug/ml using heat induced antigen retrieval in pH 6.0 citrate buffer. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | F14P4D3 | | Host | Mouse | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to human MMP2. Species sequence homology: gorilla, gibbon, monkey, panda, canine, equine, rabbit 100%; marmoset, mouse, rat, hamster, elephant, porcine, chicken xenopus 92%; bat, bovine, opossum 85%. | | Specificity | Recognizes human MMP2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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