Anti -MMP2 (72kD Type IV Collagenase, 72kD Gelatinase, Matrix Metalloproteinase-2, MMP-2,
Gelatinase A, TBE-1, CLG4A)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Matrix metalloproteinase-2 (MMP2) is a Type IV collagenase, 72kD, which is also known as gelatinase and is a member of a group of secreted zinc metalloproteases. The MMP2 gene is 17kb long with 13 exons varying in size from 110-901bp and 12 introns ranging from 175 to 4,350bp 3, located within a region of human chromosome 16q13. In addition,The extra exons encode the aa of the fibronectin-like domain which has so far been found in only the 72-92kD type IV collagenase. MMP2, which has a critical role in the binding of progelatinase A and TIMP4 via the C-terminal hemopexin-like domain (C domain), is functionally associated on the surface of angiogenic blood vessels. NOT only is a likely effector of endometrial menstrual breakdown, MMP2 is also effector and regulator of the inflammatory response. Moreover, MMP2 could be helpful in diagnosing Takayasu arteritis. | | | Catalog # | M2420-53D | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 5-10ug/ml | | Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide corresponding to second half of human MMP-2. | | Specificity | Recognizes human MMP-2. Species sequence homology: Bovine, mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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