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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP2 (72kD Type IV Collagenase, 72kD Gelatinase, Matrix Metalloproteinase-2, MMP-2, Gelatinase A, TBE-1, CLG4A)

Anti -MMP2 (72kD Type IV Collagenase, 72kD Gelatinase, Matrix Metalloproteinase-2, MMP-2,
Gelatinase A, TBE-1, CLG4A)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Matrix metalloproteinase-2 (MMP2) is a Type IV collagenase, 72kD, which is also known as gelatinase and is a member of a group of secreted zinc metalloproteases. The MMP2 gene is 17kb long with 13 exons varying in size from 110-901bp and 12 introns ranging from 175 to 4,350bp 3, located within a region of human chromosome 16q13. In addition,The extra exons encode the aa of the fibronectin-like domain which has so far been found in only the 72-92kD type IV collagenase. MMP2, which has a critical role in the binding of progelatinase A and TIMP4 via the C-terminal hemopexin-like domain (C domain), is functionally associated on the surface of angiogenic blood vessels. NOT only is a likely effector of endometrial menstrual breakdown, MMP2 is also effector and regulator of the inflammatory response. Moreover, MMP2 could be helpful in diagnosing Takayasu arteritis.
Catalog #M2420-53D
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 5-10ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to second half of human MMP-2.
SpecificityRecognizes human MMP-2. Species sequence homology: Bovine, mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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