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You are here:Home » Antibodies » Antibodies-Matrix Metalloproteinases » Anti -Matrix Metalloproteinase 2 (MMP-2, Collagenase IV, Gelatinase A)

Anti -Matrix Metalloproteinase 2 (MMP-2, Collagenase IV, Gelatinase A)


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Clone Host Grade Applications
Monoclonal Mouse Purified B IH
MMPs each have different substrate specificities within the ECM and are important in its degradation. MMP-2 mainly degrades type IV collagen and denatured collagens. MMP activity is modulated by tissue inhibitors of metalloproteinases (TIMP). Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by TIMP have been implicated in the invasive potential of malignant tumors.
Catalog #M2420-57
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1-5ug/ml
Immunohistochemistry (Paraffin using PLP fixation): 1-5ug/ml Not tested in traditional formalin fixed tissues.
Immunohistochemistry (Frozen): 0.9ug/ml
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
Clone No2Q520
FormSupplied as a liquid in 0.1M PBS, pH 7.0, 2% BSA (protease free).
ImmunogenSynthetic oligopeptide corresponding to aa468-483, VTPRDKPMGPLLVATF of human MMP-2.
SpecificityRecognizes the precursor and active forms of human MMP-2. Species Crossreactivity: mouse, rat, rabbit, porcine, bovine and equine MMP-2. Does not crossreact with human MMP-1, 3, 9 or 13.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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