Anti -MMP-2, ID (72kD Type IV Collagenase, 72kD Gelatinase, Gelatinase A, Matrix
Metalloproteinase-2, TBE-1, MMP2, CLG4A)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH |
|
| Matrix metalloproteinases (MMPs), also called matrixins, belong to a family of proteases that are essential for the breakdown of extracellular matrix (ECM). They are thus important in apoptosis, tumor cell growth, invasion, and metastasis as well as angiogenesis and wound healing. Most of the MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin-like (Hpx) domain. MMP-2 and MMP-9, the two gelatinases, contain three additional repeats of a fibronectin type II-like domain, enabling them to bind to and break down collagens. Studies on the zebrafish model have illuminated the function of MMP-2 on the remodeling, fin regeneration, and gastrulation. | | | Catalog # | M2420-59A | | Applications | Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:5000-1:20,000 | | Western Blot: 1:500-1:1000 | | Immunohistochemistry: 1:50-1:200 | | Optimal dilutions to be determined by the researcher. | | Control Peptide | M2420-59B | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Zebrafish | | Concentration | As reported | | Form | Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the intermediate region of zebrafish MMP-2. | | Specificity | Recognizes zebrafish MMP-2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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