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You are here:Home » Antibodies » Antibodies-Matrix Metalloproteinases » Anti -Matrix Metalloproteinase 3 (MMP-3, Stromelysin-1, SL-1, Transin)

Anti -Matrix Metalloproteinase 3 (MMP-3, Stromelysin-1, SL-1, Transin)


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Clone Host Grade Applications
Monoclonal Mouse Purified E B IH
MMPs are frequently expressed in malignant neoplastic cells and are thought to play crucial roles in tumor invasion and metastasis. Tissue inhibitors of matrix metalloproteinases (TIMPs) represent a family of ubiquitous proteins whose main biological function resides in their ability to control the activity of MMPs. MMP secretion by microvascular endothelial cells is an essential initial step in the formation of new blood vessels (neo-angiogenesis). Since angiogenesis does not occur in large blood vessels, it was investigated whether the secretion of MMPs and TIMPs differs between micro- and macro-vascular endothelial cells. Cultured endothelial cells derived from microvascular vs. macrovascular tissues exhibit different MMP and TIMP secretory profiles.
Catalog #M2421-19
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: Paraffin-embedded tissues
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No2Q522
FormSupplied as a liquid in 0.1M PBS, pH 7.0, 2% BSA (protease free).
ImmunogenRabbit uterine cervical fibroblasts.
SpecificityRecognizes the precursor and active forms of rabbit MMP-3. Does not crossreact with mouse or rat MMP-3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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