Anti -MMP-9 Matrix Metalloproteinase 9 (MMP-9, Gelatinase B, Collagenase 4)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IH IC FC |
|
| Matrix metalloproteinase (MMP)-9 (92-kD Type IV collagenase) belongs to the MMP family of zinc-dependent endopeptidases that has been associated with tumor cell invasion and metastasis and tumor-induced angiogenesis. As a secreted MMP, pro-MMP-9 is released into the extracellular environment by both tumor and stroma cells, where it fulfills its proteolytic functions degrading both extracellular matrix (ECM) and non-ECM proteins (1). MMP-9 is also reported to have proteolytic activity against connective tissue proteins, and has been suggested to be important in the connective tissue remodeling processes associated with atherogenesis and plaque rupture (2). MMP-9 is predominantly expressed in neutrophils, macrophages, and mast cells and has been found to be involved in a variety of autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, systemic sclerosis, rheumatoid arthritis, multiple sclerosis, polymyositis and atherosclerosis. It plays either a primary or secondary role in each one of those autoimmune diseases by its up or down-regulation, making it a target for therapy of autoimmune diseases (3, 4). | | | Catalog # | M2425-09A | | Applications | Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000-1:10,000 | | Immunohistochemistry: 1:100-1:250 | | Immunocytochemistry: 1:250-1:500 | | Flow Cytometry: 1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9E365 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in buffer, 0.05% BSA, 0.01% sodium azide, 50% glycerol. | | Purity | Supernatant | | Immunogen | A synthetic peptide corresponding to residues of human MMP-9. | | Specificity | Recognizes human MMP-9. Species crossreactivity: rat | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | 92kD type IV collagenase, 92kD gelatinase, Gelatinase B, GELB |
External Links
|
