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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-9 Matrix Metalloproteinase 9 (MMP-9, Gelatinase B, Collagenase 4)

Anti -MMP-9 Matrix Metalloproteinase 9 (MMP-9, Gelatinase B, Collagenase 4)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC FC
Matrix metalloproteinase (MMP)-9 (92-kD Type IV collagenase) belongs to the MMP family of zinc-dependent endopeptidases that has been associated with tumor cell invasion and metastasis and tumor-induced angiogenesis. As a secreted MMP, pro-MMP-9 is released into the extracellular environment by both tumor and stroma cells, where it fulfills its proteolytic functions degrading both extracellular matrix (ECM) and non-ECM proteins (1). MMP-9 is also reported to have proteolytic activity against connective tissue proteins, and has been suggested to be important in the connective tissue remodeling processes associated with atherogenesis and plaque rupture (2). MMP-9 is predominantly expressed in neutrophils, macrophages, and mast cells and has been found to be involved in a variety of autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, systemic sclerosis, rheumatoid arthritis, multiple sclerosis, polymyositis and atherosclerosis. It plays either a primary or secondary role in each one of those autoimmune diseases by its up or down-regulation, making it a target for therapy of autoimmune diseases (3, 4).
Catalog #M2425-09A
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:10,000
Immunohistochemistry: 1:100-1:250
Immunocytochemistry: 1:250-1:500
Flow Cytometry: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E365
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in buffer, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues of human MMP-9.
SpecificityRecognizes human MMP-9. Species crossreactivity: rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names92kD type IV collagenase, 92kD gelatinase, Gelatinase B, GELB


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