Anti -Matrix Metalloproteinase 11 (MMP-11, MMP11, Matrix metalloproteinase-11, Stromelysin
3, Stromelysin-3, Stromelysin III, Stromelysin-III, SL-3, ST-3, ST3, STMY3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
IH |
|
| Human MMP-11, a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodelling associated with embryonic development, wound healing and tumor invasion. Unlike other MMPs, pro-MMP-11 is processed intracellularly by furin dependent proteolytic cleavage and is then secreted in a potentially active form, suggesting that it may have a unique role among the MMPs. During malignancy, the cellular function of MMP-11 is proposed to favor survival of cancer cells in the stromal microenvironment by decreasing cancer cell death through apoptosis and necrosis. It has a dual function during cancer progression being a tumor enhancer in early stages and repressor in processes leading to local or distal invasion. Its expression has been reported in lung, colorectal, ovarian, and head and neck carcinomas. | | | Catalog # | M2427-23A | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Placenta | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E269 | | Host | Mouse | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Ascites | | Immunogen | Recombinant corresponding to active form of human MMP-11. Cellular Localization: Cytoplasmic. | | Specificity | Recognizes human MMP-11. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Matrix Metalloproteinase 11 (MMP-11, MMP11, Matrix metalloproteinase-11, Stromelysin 3, Stromelysin-3, Stromelysin III, Stromelysin-III, SL-3, ST-3, ST3, STMY3) |
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