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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -Matrix Metalloproteinase 11 (MMP-11, MMP11, Matrix metalloproteinase-11, Stromelysin 3, Stromelysin-3, Stromelysin III, Stromelysin-III, SL-3, ST-3, ST3, STMY3)

Anti -Matrix Metalloproteinase 11 (MMP-11, MMP11, Matrix metalloproteinase-11, Stromelysin
3, Stromelysin-3, Stromelysin III, Stromelysin-III, SL-3, ST-3, ST3, STMY3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites IH
Human MMP-11, a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodelling associated with embryonic development, wound healing and tumor invasion. Unlike other MMPs, pro-MMP-11 is processed intracellularly by furin dependent proteolytic cleavage and is then secreted in a potentially active form, suggesting that it may have a unique role among the MMPs. During malignancy, the cellular function of MMP-11 is proposed to favor survival of cancer cells in the stromal microenvironment by decreasing cancer cell death through apoptosis and necrosis. It has a dual function during cancer progression being a tumor enhancer in early stages and repressor in processes leading to local or distal invasion. Its expression has been reported in lung, colorectal, ovarian, and head and neck carcinomas.
Catalog #M2427-23A
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlPlacenta
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11E269
HostMouse
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PurityAscites
ImmunogenRecombinant corresponding to active form of human MMP-11. Cellular Localization: Cytoplasmic.
SpecificityRecognizes human MMP-11.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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