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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-13, Hinge (Collagenase 3, Matrix Metalloproteinase-13, MMP13)

Anti -MMP-13, Hinge (Collagenase 3, Matrix Metalloproteinase-13, MMP13)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
The matrix metalloproteinases (MMPs) constitute a family of zinc-dependent endopeptidases that function within the extracellular matrix. These enzymes are responsible for the breakdown of connective tissues and are important in bone remodeling, menstrual cycle and the repair of tissue damage. MMP-13 (collagenase-3) is a member of the MMP family of 37 extracellular proteases. Targets of MMP-13 include collagen, gelatin, aggracan, plasminogen and CXCL12. MMP-13 is secreted as a 60kD proenzyme (as measured by SDS-PAGE), and activated by cleavage to a mature 48kD MMP-13. MMP-13 is an important target for inhibitor screening due to its involvement in diseases such as cancer and arthritis.
Catalog #M2427-23D
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000 or 1-2ug/ml
Immunohistochemistry: 5-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05 % sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the hinge region of human MMP-13.
SpecificityRecognizes human MMP-13. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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