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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -Matrix Metalloproteinase 11 (MMP-11, Stromelysin 3)

Anti -Matrix Metalloproteinase 11 (MMP-11, Stromelysin 3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
Stromelysin, a member of the matrix metalloproteinase family, demonstrates wide substrate specificity with the ability to degrade proteoglycan, fibronectin, laminin, casein, and the nonhelical region of collagen. The stromelysin-3 (MMP-11) gene was originally identified on the basis that it is expressed specifically in stromal cells surrounding invasive breast carcinomas. MMP-11 is localized by in situ hybridization to the long arm of chromosome 22. The MMP-11 expression is found more specifically in malignant tumors than in benign ones.
Catalog #M2427-29
ApplicationsSuitable for use in Immunoprecipitation, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunoprecipitation (Native verified): 2ug/mg protein lysate. Use Protein G
Western Blot: 0.5-1.0ug/ml for 2 hours at RT
Immunohistochemistry (Formalin/paraffin): 1-2ug/ml for 30 minutes at RT. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues.
The optimal dilution should be determined by the researcher.
Positive ControlRecombinant MMP-11 protein. Placenta.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No3F268
HostMouse
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See M2427-29X
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to active form of human MMP-11. MW of Antigen
SpecificityRecognizes human MMP-11 (Stromelysin 3). Preferred for sensitive detection of MMP-11 by Western Blot as well as for staining of routine formalin-fixed, paraffin-embedded tissues.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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