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You are here:Home » Antibodies » Antibodies-Matrix Metalloproteinases » Anti -MMP12 (Macrophage Metalloelastase, MME, Matrix Metalloproteinase-12, MMP-12, Macrophage Elastase, ME, hME, HME)

Anti -MMP12 (Macrophage Metalloelastase, MME, Matrix Metalloproteinase-12, MMP-12,
Macrophage Elastase, ME, hME, HME)


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.
Catalog #M2427-59D
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:4000
Western Blot: 0.3-1ug/ml, observed in human breast cancer lysates on ~55kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-RPKTSVNLISS, from human MMP12, at the internal region of the protein (NP_002417.2).
SpecificityRecognizes human MMP12. Species sequence homology: Bovine and canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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