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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-14 (Matrix Metalloproteinase-14, MMP-X1, Membrane-type Matrix Metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 Matrix Metalloproteinase, MT1-MMP, MT1MMP, MMP14)

Anti -MMP-14 (Matrix Metalloproteinase-14, MMP-X1, Membrane-type Matrix Metalloproteinase
1, MT-MMP 1, MTMMP1, Membrane-type-1 Matrix Metalloproteinase, MT1-MMP, MT1MMP, MMP14)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family, ten exist in soluble form, whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8aa insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2, forming a trimer. It cleaves the pro-MMP-2 to its active form.
Catalog #M2429-02A
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:30 for 10min at RT
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10min followed by cooling at RT for 20min
Optimal dilutions to be determined by the researcher.
Positive ControlPlacenta, breast carcinoma
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa160-173 from human MMP-14.
SpecificityRecognizes human MMP-14.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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