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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-15 (Matrix Metalloproteinase-15, Membrane-type Matrix Metalloproteinase 2, MT-MMP 2, MTMMP2, Membrane-type-2 Matrix Metalloproteinase, MT2-MMP, MT2MMP, SMCP-2, MMP15)

Anti -MMP-15 (Matrix Metalloproteinase-15, Membrane-type Matrix Metalloproteinase 2,
MT-MMP 2, MTMMP2, Membrane-type-2 Matrix Metalloproteinase, MT2-MMP, MT2MMP, SMCP-2,
MMP15)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family, ten exist in soluble form, whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8aa insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Co-expression of MT1-MMP and MT2- MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.
Catalog #M2430-04A
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:50 for 10min at RT
Optimal dilutions to be determined by the researcher.
Positive ControlPlacenta
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the catalytic domain of mouse MMP-15.
SpecificityRecognizes mouse MMP-15. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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