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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-21 (Matrix Metallopeptidase 21, Mmp21)

Anti -MMP-21 (Matrix Metallopeptidase 21, Mmp21)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
Matrix metalloproteinases (MMP) belong to a family of proteases that are essential for the breakdown of extracellular matrix. Thus they play an important role in apoptosis, and tumor cell growth, invasion, and metastasis, as well as in angiogenesis and wound healing. All MMPs contain the common domain structures, which include a signal sequence, a propeptide, a catalytic domain and a hemopexin-like (Hpx) domain. Human MMP-21 is the probable target gene of the Wnt pathway. In addition, the expression of MMP-21 is controlled uniquely by Pax and Notch transcription factors known to be critical for organogenesis. MMP-21 is expressed transiently in mouse embryogenesis and increased in embryonic neuronal tissues. Our observations clearly indicate that there is an important specific function for MMP-21 in embryogenesis, especially in neuronal cells.
Catalog #M2435-42
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Optimal dilutions to be determined by the researcher.
Control Peptide M2435-42P
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the intermediate region of zebrafish MMP- 21.
SpecificityRecognizes zebrafish MMP-21.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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