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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-2, hinge region (matrix metallopeptidase 2, 72kD Gelatinase, 72kD Type IV Collagenase, CLG4, CLG4A, Gelatinase A, Matrix Metalloproteinase-2, MMP-II, MONA, TBE-1)

Anti -MMP-2, hinge region (matrix metallopeptidase 2, 72kD Gelatinase, 72kD Type IV
Collagenase, CLG4, CLG4A, Gelatinase A, Matrix Metalloproteinase-2, MMP-II, MONA, TBE-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, atherosclerosis, and in cancer cell invasion and metastasis. MMP2, also known as Gelatinase A, is a type IV collagenase that specifically cleaves type IV collagen, the major structural component of basement membranes. The metastatic potential of tumor cells has been found to correlate with the activity of this enzyme.
Catalog #M2436-01A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlA431 cell lysate.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide selected from the hinge region of human MMP-2. Epitope: Hinge region
SpecificityRecognizes human MMP-2. It does not cross react with MMP-1, MMP-8, MMP-9, MMP-13, and MMP-14. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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