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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-24, Hinge (Matrix Metalloproteinase-24, MMP24, Membrane-type Matrix Metalloproteinase 5, MT-MMP 5, MTMMP5, Membrane-type-5 Matrix Metalloproteinase, MT5-MMP, MT5MMP, MT5MMP)

Anti -MMP-24, Hinge (Matrix Metalloproteinase-24, MMP24, Membrane-type Matrix
Metalloproteinase 5, MT-MMP 5, MTMMP5, Membrane-type-5 Matrix Metalloproteinase, MT5-MMP,
MT5MMP, MT5MMP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Matrix metalloproteinases (MMP) belong to a family of proteases that are essential for the breakdown of extracellular matrix. Thus they play an important role in apoptosis, and tumor cell growth, invasion, and metastasis, as well as in angiogenesis and wound healing. All MMPs contain a common domain structure, which include a signal sequence, a propeptide, a catalytic domain and a hemopexin-like (Hpx) domain. MMP-24 (MT5-MMP), the fifth cloned MT- MMP, is expressed in few tissues including testes, liver, lung and kidney; however, it is predominately found in the nervous system. MMP-24 expression is ubiquitously expressed during neural development; while in the adult CNS, it is restricted to specific regions, some of which are known to be neurogenic, such as the hippocampus. The MMP-24 was also studied in the Danio Rerio (zebrafish).
Catalog #M2436-05A
ApplicationsSuitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.
Control Peptide M2436-05P
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the hinge region of zebrafish MMP-24.
SpecificityRecognizes zebrafish MMP-24.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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