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Abs to Matrix Metalloproteinases
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Anti -MMP28, ID (Matrix Metalloproteinase-28, MMP-28, Epilysin, MMP25, UNQ1893/PRO4339)
Anti -MMP28, ID (Matrix Metalloproteinase-28, MMP-28, Epilysin, MMP25, UNQ1893/PRO4339)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Matrix metalloproteinases (MMPs) belong to the subfamily of metzincin peptidases. These proteins have the ability to cleave and remodel the extracellular matrix, and play a critical role in modifying cell behavior during periods of wound repair, embryonic development, and also cancer progression. Substrates of MMPs include cell adhesion molecules, growth factors, and cytokines and proteases. Epilysin (MMP-28) is expressed primarily in migrating and stationary keratinocytes in the skin during wound healing, but also expressed in testis germ cells and cancer cells. Located solely on chromosome 17, Epilysin has been studied to have a significant role on cells undergoing epithelial to mesenchymal transition (EMT), which is a hallmark of embryonic and carcinoma development and results in loss of cell-to-cell E-cadherin adhesion, along with increased expression of TGF-beta. | | | Catalog # | M2438-18B | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | MCF-7 cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to a 17aa internal sequence of human MMP-28. | | Specificity | Recognizes human MMP-28. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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