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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -MCAF (MBD1-containing Chromatin Associated Factor, MCAF1, Activating Transcription Factor 7 Interacting Protein 1, ATF7IP, ATF Interacting Protein, ATF-IP, ATFa-associated Modulator, hAM, p621)

Anti -MCAF (MBD1-containing Chromatin Associated Factor, MCAF1, Activating Transcription
Factor 7 Interacting Protein 1, ATF7IP, ATF Interacting Protein, ATF-IP, ATFa-associated
Modulator, hAM, p621)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
MBD1-containing chromatin-associated factor (MCAF) is a 1270-residue mediator in the DNA methylation cycle of a variety of genomic functions. This nuclear protein will bind to the C-terminal transcriptional repression domain of MBD1 to form a blocking complex. This molecule will then prevent transcription from methylated promoters in a histone deacetylation-independent action.
Catalog #M2690-19B
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:5000-1:20,000
Immunohistochemistry (Frozen/paraffin): 1:10-1:500
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa Nuclear Extract
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in Tris-citrate/phosphate buffer, pH 7.5, 0.1% sodium azide
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa25-100 of human MCAF (AAQ92978.1)(GeneID 55729).
SpecificityRecognizes human MCAF. Species Sequence Homology: mouse based upon conservation between this ortholog and human MCAF at the site to which the epitope maps.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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