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Abs to DNA Replication, Repair
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Anti -MCM7 (DNA Replication Licensing Factor MCM7, CDC47 Homolog, P1.1-MCM3, CDC47, MCM2)
Anti -MCM7 (DNA Replication Licensing Factor MCM7, CDC47 Homolog, P1.1-MCM3, CDC47, MCM2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
IH |
|
| The CDC47 (MCM7) protein encoded by this gene is one of the highly conserved mini-chromosome maintenance (MCM) proteins which identify a group of ten conserved factors functioning in the replication of the genomes of archae and eukaryotic organisms. Among these, MCM hexameric protein complex consisting of 2, 3, 4, 5 6 and 7 proteins are related to each other and form a family of DNA helicases implicated at the initiation step of DNA synthesis. The MCM2-7 proteins bind to chromatin in a cell-cycle-dependent manner, being tightly bound in late mitosis and G1 while being removed in S- and G2-phases. MCM2-7 proteins play a role in the initiation step of DNA synthesis as DNA helicases that melt the DNA double helix. They are recruited to DNA replication origins in a highly regulated reaction at mitotic exit, leading to formation of the pre-replicative complex (pre-RC). Cyclin D1-dependent kinase, CDK4, is found to associate with MCM7protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. | | | Catalog # | M2749-37H | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Breast carcinoma | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E274 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Purified | | Immunogen | Recombinant corresponding to human CDC47 protein. Cellular Localization: Nuclear. | | Specificity | Recognizes CDC47. Species Crossreactivity: canine, mouse, rat, Xenopus. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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