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You are here:Home » Antibodies » Abs to DEAD Box Proteins » Anti -MDA5 (Melanoma Differentiation-Associated Protein 5, DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide, Helicard, Hlcd, Helicase with 2 CARD Domains, IDDM19, Interferon-induced with Helicase C Domain Protein 1, Interferon-induced Helicase C Domain-containing P

Anti -MDA5 (Melanoma Differentiation-Associated Protein 5, DEAD/H (Asp-Glu-Ala-Asp/His)
Box Polypeptide, Helicard, Hlcd, Helicase with 2 CARD Domains, IDDM19, Interferon-induced
with Helicase C Domain Protein 1, Interferon-induced Helicase C Domain-containing P

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E IH
Catalog #M2772-75D
Gene ID 64135
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in TBS, pH 7.2, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: SNGYSTDENFRYL representing the N-Terminus of the human protein (residues 2-14), according to NP_071451.
SpecificitySpecies Crossreactivity: Reacts with Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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